The childhood sweetheart revisited.
High-voltage-activated calcium (CaV) channels link electrical signals to the inflow of Ca2+ ions that trigger biological responses in excitable cells. CaV channels are macromolecular complexes containing pore-forming alpha1 proteins minimally assembled with auxiliary beta and alpha2delta subunits. Both CaVbeta and alpha2delta subunits augment CaV channel currents by enhancing alpha1 trafficking to the cell surface. Whereas CaVbeta (the childhood sweetheart) associates early with alpha1 in the endoplasmic reticulum and promotes forward trafficking.