Many of us have had moments when we wonder why we are pursuing things that are of little real interest to us. Often, we conclude that we don't really have a choice but to pick a well-trodden path of reasonable comfort and predictability, that can be easily understood by our peers and family.
We are all autonomous, but we let external ideas and limited thinking be our guides. The common belief of “the system” as well as the acceptance of external ideas of good and bad, limit individual potential. The more that one accepts and lives by fixed ideas rather than thinking from first principles, the less one can realize themselves as individuals and ultimately live a fulfilling life. ( See The Foundation of Individual Autonomy http://comprehensophy.blogspot.com/…/the-foundation-of-indi… ).
So it should be fairly clear to us why we have a problem today with meaninglessness (you see it a lot, "the age of meaninglessness", etc.). The suicide, depression, addiction, search for easy answers, and reliance on passive pleasure among people all over the world is a testament to the meaninglessness which has itself grown out of a problem with our thinking and minds. ( See An Example of the Externally-driven Worldview http://comprehensophy.blogspot.com/…/an-example-of-external… )