The architecture is said be a form reminiscent of a lotus flower. It is designed by the architect Moshe Safdie.
Referred to as "The Welcoming Hand of Singapore" by Las Vegas Sands chairman Sheldon Adelson, the ArtScience Museum is anchored by a round base in the middle, with ten extensions referred to as "fingers". The design concept for each finger denotes various gallery spaces sporting skylights at the "fingertips" which are included as sustainable illumination for the curved interior walls.
The ArtScience Museum has 21 gallery spaces with a total area of 50,000 square feet (6,000 square meters).
Rainwater is harvested and channelled down the center of the building, flowing through its bowl-shaped roof into a reflecting pond at the lowest level of the building. The rainwater is then recycled for use in the building's restrooms.