How CBD works in the body
You may wonder how cannabidoid enters the human cell and effectively binds to receptors. The process is intricate, yet efficient. Cannabidoid passes through cell membranes and attaches itself to Fatty Acid Binding Proteins. This particular protein travels with lipid molecules and penetrates the interior of the cells.
Interestingly, the same protein is responsible for Tetrahydrocannabinol (THC) transport, including the marijuana-like molecules produced by the brain - 2 AG and the Endocanabinoids Ananamide. Once CBD is inside the cells, the fatty acid amide hydrolase (FAAH) begins breaking down the metabolic enzyme called Anandamide. FAAH is a vital component of the molecular life cycle of the cell. click on the following link for more information
The Endocannabinoid system and cannabinoids
The cannabinoids main target is the Endocannabinoid system or ECS. It is found in the central nervous system and in the brain. All mammals have this system in their bodies. ECS is the structural, molecular system which controls the body's reaction to normal psychological processes.
This system in the body was first discovered in the late 1980s, and quickly became the subject of study because of its vital role in regulating homeostasis (general condition of balance). It corrects and mediates neural responses to help the body maintain its normal balance.
It is a signaling system which manages and controls the body's response to pain, sleep, hunger, stress, blood pressure, circadian rhythms, body temperature, moods, memory, fertility, metabolism, intestinal vitality, bone density and other vital functions.
The Endocannabinoid system responds to natural endogenous cannabinoids which are manufactured by the body. The system can be manipulated to react to externally-induced cannabinoids to cure medical ailments - hence the effectiveness of CBD supplements.
Receptors of Endocannabinoid System and CBD
The Endocannabinoid system has millions of tiny receptor sites in almost all areas of the body. However, it only has two 2 main receptors which work to bind cannabinoids - CB1 and CB2. CB1 receptors are found in the central nervous system and in the brain while CB2
receptors are located in the immune system.
They interact and work together through neural communication. The body's natural Endocannabinoids, the 2-AG and Anandamide control this cellular communication.
However, cannabidiol (CBD) from the cannabis hemp plant does not fit CB1 and CB2. So how does it work when it enters the body? CBD stimulates the receptor activities without binding itself to them. The result changes the cellular responses and can be systemic since CB1 and CB2 receptors are all over the body.
If THC is present in the system, CBD presence will counteract the known psychoactive effect of the compound on CB1 receptors.
Cytochrome P-450 System and CBD
Cannabidiol's ability to cure various illnesses can be done by manipulating the Endocannabinoid system. It is important for people to understand that CBD can be dangerous if improperly administered.
CBD can inhibit the ability of Cytochrome P-450 system to metabolize medication for certain types of diseases. Cytochrome P-450 is a system found in the liver and is responsible for breaking down 90% of the drugs you take.
This system has over 50 types of enzymes which process and flushes out toxins. CBD presence in the system does prolong the processing of drugs and its effect on the body. This may also cause higher doses of drugs in the system, and if you're not careful, this can lead to an overdose or other adverse side-effects.
It is vital to make dosage adjustments if you are taking both your medication drug and CBD. Here are some of the drugs that utilize Cytochrome P-450 system which interact with cannabidiol (CBD):
•Calcium channel blockers
•HMG CoA reductase inhibitors
•Angiotension II blockers
•Oral hypoglycemic agents
It is vital to consult your doctor before taking CBD dietary supplements so they can adjust the dosage for your other medications. While you are there, ask him to test your Cytochrome P-450 system to make sure that it is functioning excellently and metabolizing your medications as it should.