Doom II Cover
The new Doom board game looks so absolutely awesome. I must admit that I haven't played it yet, but I'm a fan already, based on reviews and FFG's (the publisher) track record alone.
They refined the one-vs-many formula of the original Doom board game from 2004 through several iterations: Descent, Descent 2nd Ed., Imperial Assault. Every iteration added and removed some things, and so does this one - there's more replayability in a single box than in any of the other ones I think, with several missions that can all be played on the provided maps and fundamentally change gameplay, the Marine player getting classes and loadouts to juggle with, and the Invader player has different sets of strategy cards that appear to change how he plays, too.
Of course, there's also the awesome-looking minis, with fine details and chunky bits.
For reference, here's the image I loosely modeled mine after: