The Binding of Isaac makes much more sense when viewed as the imaginary world of an abused kid with a shitty family who picks on him for questioning their beliefs. The whole game takes place in his mind, he creates the stories and draws them as a coping mechanism to deal with his shitty living environment. The only thing that makes him happy is rendering his brothers and sisters as horrifying monsters that he destroys with the power of his tears.
He is a little boy with intense sadness, but can still laugh at drawings of pee, poop and throw-ups. He takes joy in drawing his shit head mother as an insane zealot for god, hyperrealizing what is really sitting outside of his room staring at the t.v.
Isaac is sensitive and smart, and someday he will learn that this will come to an end, that he can be free of the moral trappings of an overly religious family crammed together into an oppressive environment. But until then he will draw his mom farting flies out of her butt, and that's ok too.
Anyway, this week I recommend The Binding of Isaac: Rebirth, the original was great, but what you can do with an actual development team is amazing.